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A shortcut I would LOVE to have is a way to close a tab/window from the tab/window itself, while saving it. Having to find it in the Outliner window is a pain when I just want to save-close it. Something along the lines of cmd-alt-w for save-close tab, and cmd-shift-alt-w for save-close window.
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For 2, you can save/open whole groups in the tree as long as you collapse it first.
For 3, you can Save tabs /if they're in a window-node with saved items, and you close the whole window at once/. But yes, I agree that a way to save individual tabs from the page itself would be nice. Vladyslav has said a keyboard shortcut for that is unlikely because it requires inserting javascript into every page, but that he might do something with option in the icon-button to do that.